Ultraviolet light induces epidermal ornithine decarboxylase activity

Journal Article · Fri Dec 01 04:00:00 EST 1978 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12558288· OSTI ID:6756764

Lowe, M; Verma, A K; Boutwell, R K

Hairless mice were irradiated with fluorescent sun lamp tubes (peak emission at 313 nm). A significant increase in epidermal ornithine decarboxylase activity was found after 2 h. A maximum 80-fold increase was found after 24 h, decreasing again at 48 h. Epidermal DNA synthesis was decreased at 6 h and 24 h increasing to a maximum 48 h after irradiation. These results show that polyamine biosynthetic enzyme activity precedes the delayed increase in epidermal DNA synthesis following ultraviolet light exposure.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 6756764
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 71:6; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560400* -- Other Environmental Pollutant Effects
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACIDS
DECARBOXYLASES
DNA
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
EPIDERMIS
EPITHELIUM
LYASES
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
ORNITHINE
RADIATION EFFECTS
RADIATIONS
RODENTS
SKIN
SYNTHESIS
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES