Binding of dexamethasone by the subcellular fractions of mouse epidermis and dermis
Journal Article
·
· J. Invest. Dermatol.; (United States)
The binding of the potent anticarcinogenic agent, dexamethasone, to mouse epidermal and dermal subcellular fractions was investigated. When applied to mouse skin, /sup 3/H-labeled dexamethasone remained associated, after extensive dialysis, with epidermal and dermal cytosol, microsomes, mitochondria, and chromatin. The specific activity of dexamethasone binding to these fractions was from 2 to 5 times as high in the epidermis as in the dermis. Epidermal chromatin had the highest specific activity of binding. Dexamethasone was not associated with the cytosol protein receptor which was previously found to specifically bind tumor promoters and polycyclic hydrocarbon carcinogens.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 7297944
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 68:5; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BINDING ENERGY
BODY
CELL CONSTITUENTS
CHROMATIN
CORTICOSTEROIDS
DEXAMETHASONE
ENERGY
EPIDERMIS
EPITHELIUM
GLUCOCORTICOIDS
HORMONES
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LIGHT NUCLEI
MAMMALS
MICE
MICROSOMES
MITOCHONDRIA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PREGNANES
RADIOISOTOPES
RODENTS
SKIN
STEROID HORMONES
STEROIDS
TISSUES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BINDING ENERGY
BODY
CELL CONSTITUENTS
CHROMATIN
CORTICOSTEROIDS
DEXAMETHASONE
ENERGY
EPIDERMIS
EPITHELIUM
GLUCOCORTICOIDS
HORMONES
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
LIGHT NUCLEI
MAMMALS
MICE
MICROSOMES
MITOCHONDRIA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PREGNANES
RADIOISOTOPES
RODENTS
SKIN
STEROID HORMONES
STEROIDS
TISSUES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES