Molecular basis for the mutagenic and lethal effects of ultraviolet irradiation. Progress report. [UV radiation, Escherichia coli, HeLa cells]

Technical Report · Sat Jan 01 04:00:00 EST 1977

OSTI ID:7294548

Pathways of DNA repair in bacteria and mammalian cells. Progress is reported on the following studies: genetic control of incision and excision in Escherichia coli; effects of binding proteins on the repair process in vitro; location of endonuclease - uv-irradiated DNA complexes; identification of eukaryotic repair mechanisms; nuclear complementation in HeLa cells; enzyme isolation from repair syndrome skin fibroblasts; and expression of the E. coli - SV40 hybrid DNA. (HLW)

• Research Organization: Johns Hopkins Univ., Baltimore, Md. (USA)
• OSTI ID: 7294548
• Report Number(s): TID-27764
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BACTERIA
BINDING ENERGY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CELL CONSTITUENTS
CELL NUCLEI
CONNECTIVE TISSUE CELLS
DNA
ELECTROMAGNETIC RADIATION
ENERGY
ENZYMES
ESCHERICHIA COLI
FIBROBLASTS
HELA CELLS
HYBRIDIZATION
KINETICS
MICROORGANISMS
NUCLEASES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOSPHOTRANSFERASES
PROTEINS
RADIATION EFFECTS
RADIATIONS
REACTION KINETICS
REPAIR
SKIN
SOMATIC CELLS
TRANSFERASES
ULTRAVIOLET RADIATION