/sup 99m/Tc--thiomalic acid complex: a nonstannous chelate for renal scanning

Journal Article · Fri Apr 01 04:00:00 EST 1977 · J. Nucl. Med.; (United States)

OSTI ID:7292371

Hagan, P L; Chauncey, Jr, D M; Halpern, S E; Ayres, P R

Thiomalic acid (monomercaptosuccinic acid) has been labeled with /sup 99m/Tc without the use of an intermediary reducing agent. Tissue distribution studies in rats following the injection of /sup 99m/Tc-tagged thiomalic acid (/sup 99m/Tc-TMA) showed 40 to 48 percent of the injected dose in the kidneys. Renal incorporation of this compound was influenced by various parameters such as pH, quantity of thiomalic acid, heating time, and the preparation-injection interval. Scintigrams of a midline kidney slice showed that the /sup 99m/Tc activity concentrated mainly in the renal cortex. As a proposed renal-imaging agent, /sup 99m/Tc-TMA compared favorably with /sup 99m/Tc-Sn-dimercaptosuccinate and /sup 99m/Tc-penicillamine regarding the percent incorporation into the kidney and was superior in this respect to /sup 99m/Tc-Sn-glucoheptonate and /sup 99m/Tc-Sn-diethylenetriamine pentaacetic acid. The /sup 99m/Tc-TMA was also shown to be highly stable through 24 hr. The reagent can be made available in kit form and is easily combined with /sup 99m/Tc in two steps. Finally, the absence of stannous ion in the /sup 99m/Tc-TMA complex should avoid the problem of interference with other procedures involving pertechnetate /sup 99m/TcO/sub 4//sup -/ as the imaging agent.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 7292371
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DICARBOXYLIC ACIDS
DRUGS
DTPA
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
PENICILLAMINE
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
SCINTISCANNING
SUCCINIC ACID
TECHNETIUM 99
TECHNETIUM ISOTOPES
THIOLS
YEARS LIVING RADIOISOTOPES