Glucoheptonate measurement of differential renal function. [Dogs]

Journal Article · Sun Jul 01 00:00:00 EDT 1984 · J. Urol.; (United States)

OSTI ID:6349550

Powers, T A; Stone, W J; Witt, W S; Killion, L T; Patton, J A

In previous studies using dogs whose renal function was rendered asymmetric by unilateral infarction or partial ureteral obstruction, the efficacy of technetium-99m diethylenetriamine pentaacetic acid and dimercaptosuccinic acid in the measurement of differential renal function was demonstrated. The present study was undertaken to determine if technetium-99m glucoheptonate could also be used to quantitate differential renal function in these conditions. Five dogs with partial ureteral obstruction, 4 with segmental infarction and 2 with ipsilateral combination of both were studied. Seven to 10 days following these interventions the animals were given a bolus injection of 10 mCi Tc-99m glucoheptonate. Static images were obtained anteriorly and posteriorly between 3 and 5 hours postinjection. The following day iothalamate and creatinine clearances were measured by ureteral catheterization. There was good correlation between differential function calculated from the 1 to 3 minute portion of the bolus study and that determined by the ureteral catheter studies. Correlations based on the static images were less satisfactory due to pelvic retention in the obstructed animals. The authors conclude that technetium-99m glucoheptonate may be used to determine differential renal function.

• Research Organization: Veterans Administration Medical Center, Nashville, TN
• OSTI ID: 6349550
• Journal Information: J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 132:1; ISSN JOURA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID ESTERS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
DYNAMIC FUNCTION STUDIES
ESTERS
GLUCOHEPTONATE
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES