Radionuclide measurement of differential glomerular filtration rate

Journal Article · · Invest. Radiol.; (United States)

DOI:https://doi.org/10.1097/00004424-198101000-00011· OSTI ID:5638676

Powers, T A; Stone, W J; Grove, R B; Plunkett, J M; Kadir, S; Patton, J A; Bowen, R D

The authors sought to determine whether radionuclides could provide a reasonable estimate of differential renal function in five normal dogs and six dogs with unilateral segmental renal infarction. Glomerular filtration rate (GFR) of each kidney was measured by the standard technique using constant infusions of /sup 99m/Tc-DTPA, iothalamate, and creatinine following ureteral catheterization. These results were correlated with total GFR estimated by bolus injection of /sup 99m/Tc-DTPA and analysis of the plasma /sup 99m/Tc-DTPA disappearance curve obtained by blood sampling. Differential GFR was then calculated by multiplying the total GFR from double exponential analysis of this curve (DTPA2) by each of three measures of differential function. These include the percent differential uptake of /sup 99m/Tc-DTPA and /sup 99m/Tc-DMSA in the posterior projection as well as the geometric mean of /sup 99m/Tc-DMSA uptake. There were good correlations between differential GFR calculated from iothalamate clearances obtained at ureteral catheterization and all noninvasive methods involving radionuclides and DTPA2 (r . 0.85 - 0.99). Single exponential analysis of the /sup 99m/Tc-DTPA plasma disappearance curve was less satisfactory. The authors suggest that measurement of total and differential GFR calculated from plasma clearance of /sup 99m/Tc-DTPA and external counting may be a useful method with potential clinical applications.

• OSTI ID: 5638676
• Journal Information: Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 16:1; ISSN INVRA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPARATIVE EVALUATIONS
CREATININE
DOGS
DRUGS
DTPA
DYNAMIC FUNCTION STUDIES
EXCRETION
FILTRATION
GLOMERULI
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPROTECTIVE SUBSTANCES
RENAL CLEARANCE
SEPARATION PROCESSES
TECHNETIUM 99
TECHNETIUM ISOTOPES
ULTRAFILTRATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES