Radioimmunoassay for measurement of thyroxine (T/sub 4/) and triiodothyronine (T/sub 3/) in blood serum

Patent · Tue Oct 07 04:00:00 EDT 1975

OSTI ID:7287050

Chopra, I J

This invention relates to a highly accurate, rapid and simple estimation of thyroxine (T/sub 4/) directly from blood serum and also relates to the accurate measurement of triiodo-L-thyronine (T/sub 3/) directly from blood serum. More specifically, the invention relates to a rapid, specific and reliable radioimmunoassay (RIA) technique for measurement of both T/sub 4/ and T/sub 3/ in unextracted serum. The method requires very small amounts of serum, e.g., 25 microliters (..mu..l) to measure T/sub 4/ concentration in nearly all specimens representing clinical states of eu-, hypo- and hyperthyroidism, and 250 ..mu..l to measure T/sub 3/ concentrations in specimens representing most clinical states.

• Assignee: Professional Staff Association of the Los Angeles County Harber General Hospital
• Patent Number(s): US 3911096
• OSTI ID: 7287050
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
BLOOD SERUM
CARBOXYLIC ACIDS
DISEASES
ENDOCRINE DISEASES
HORMONES
HYPERTHYROIDISM
ISOTOPE APPLICATIONS
MAMMALS
MAN
MEASURING METHODS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
PEPTIDE HORMONES
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
THYROID HORMONES
THYROXINE
TRACER TECHNIQUES
TRIIODOTHYRONINE
VERTEBRATES