Radioimmunoassay for measurement of thyroxine (T$sub 4$) and triiodothyonine (T$sub 3$) in blood serum

Patent · Wed Oct 01 04:00:00 EDT 1975

OSTI ID:4092967

Chopra, I J

This invention relates to a highly accurate, rapid and simple estimation of thyroxine (T$sub 4$) directly from blood serum and also relates to the accurate measurement of triiodo-L-thyronine (T$sub 3$) directly from blood serum. More specifically, the invention relates to a rapid, specific and reliable radioimmunoassay (RIA) technique for measurement of both T$sub 4$ and T$sub 3$ in unextracted serum. The method requires very small amounts of serum, e.g., 25 microliters ($mu$l) to measure T$sub 4$ concentration in nearly all specimens representing clinical states of eu-, hypo- and hyperthyroidism, and 250 $mu$l to measure T$sub 3$ concentrations in specimens representing most clinical states. (auth)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-33-020582
• Assignee: to Los Angeles County Harbor General Hospital
• Patent Number(s): US 3911096
• OSTI ID: 4092967
• Country of Publication: United States
• Language: English

Related Subjects

*THYROXINE-- RADIOIMMUNOASSAY
*TRIIODOTHYRONINE-- RADIOIMMUNOASSAY
550601* --Biomedical Sciences
Basic Studies--Medicine-- Unsealed Radionuclides in Diagnostics
BLOOD SERUM
HYPERTHYROIDISM
HYPOTHYROIDISM
N48730* --Life Sciences--Nuclide Kinetics & Toxicology-- Plants