The role of superoxide radicals in the oxygen enhancement of radiation damage. Final report 1 Jul 74--29 Jun 77
Technical Report
·
OSTI ID:7286990
The oxygen enhancement of the lethality of x-ray irradiation of dilute suspensions of Escherichia coli is strikingly diminished by superoxide dismutase or by catalase, added to the suspending medium. This implicates both O2(-) and H2O2 as agents of the O.E.R. Since O2(-) and H2O2 have previously been seen to lead to the production of OH in biochemical systems, the effects are tested of scavengers of such radicals. As expected, mannitol or histidine also decreased the O.E.R. Since catalase and superoxide dismutase could be shown not to move from the medium into the cells, the protections caused by these enzymes were due to actions in the suspending medium. Hence O2(-) and H2O2 generated in the medium are intermediates in the O.E.R.
- Research Organization:
- Duke Univ., Durham, N.C. (USA). Medical Center
- OSTI ID:
- 7286990
- Report Number(s):
- AD-A-046644
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CATALASE
CHALCOGENIDES
CRYOGENIC FLUIDS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENZYMES
ESCHERICHIA COLI
FLUIDS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INJURIES
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
MICROORGANISMS
NONMETALS
OXIDES
OXIDOREDUCTASES
OXYGEN
OXYGEN COMPOUNDS
PEROXIDES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
TOXICITY
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CATALASE
CHALCOGENIDES
CRYOGENIC FLUIDS
ELECTROMAGNETIC RADIATION
ELEMENTS
ENZYMES
ESCHERICHIA COLI
FLUIDS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
INJURIES
IONIZING RADIATIONS
IRRADIATION
LETHAL IRRADIATION
MICROORGANISMS
NONMETALS
OXIDES
OXIDOREDUCTASES
OXYGEN
OXYGEN COMPOUNDS
PEROXIDES
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
TOXICITY
X RADIATION