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Superoxide dismutase and the oxygen enhancement of radiation lethality. [X radiation, Escherichia coli]

Journal Article · · Arch. Biochem. Biophys.; (United States)
Escherichia coli B were more susceptible to radiation lethality and showed a greater oxygen enhancement ratio when exposed in dilute suspension (1 x 10/sup 5/ cells/ml) than when exposed in dense suspensions (1 x 10/sup 9/ CELLS/ml). The oxygen enhancement, seen with dilute suspensions, was diminished by superoxide dismutase, catalase, mannitol, or histidine. Heat-denatured superoxide dismutase was without effect. The results are interpreted as indicating a role for O/sub 2//sup -/ plus H/sub 2/O/sub 2/ in the oxygen enhancement of radiation lethality, and a scheme is proposed which is consistent with the observations.
Research Organization:
Duke Univ., Durham, NC
OSTI ID:
7216548
Journal Information:
Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 176; ISSN ABBIA
Country of Publication:
United States
Language:
English