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Investigation of intrarenal blood flow and urine flow aspects by scintillation camera

Journal Article · · Invest. Urol.; (United States)
OSTI ID:7282293
In order to clarify intrarenal dynamic processes related to regional distribution in patients with unilateral renal disease, two radioactive tracers, /sup 133/Xe and /sup 99m/Tc-diethylenetriaminepentaacetic acid (/sup 99m/Tc-DTPA) were introduced into a renal artery and intrarenal blood flow and urine flow aspects were observed by scintillation camera. Cortical blood flow decreased and medullary blood flow relatively increased with the advance of renal damage. Urine flow curve from normal cortex showed two phasic patterns. One early phase might correspond to the appearance of the tracer through the proximal tubule and a second phase might correspond to the appearance of the tracer through the loop of Henle to the distal tubule. Under mannitol diuresis, two phasic urine flow curves from the cortex became obscured and the peak time of pelvic curve shifted to the earlier period. These studies were considered to be useful in evaluating unilateral renal function and might offer a good insight for intrarenal physiology concerning blood flow as well as urine flow.
Research Organization:
Kyoto Univ.
OSTI ID:
7282293
Journal Information:
Invest. Urol.; (United States), Journal Name: Invest. Urol.; (United States) Vol. 14:4; ISSN INURA
Country of Publication:
United States
Language:
English