Computer assisted nuclear assessment of renal perfusion in a two kidney, one clip canine model of Goldblatt hypertension

Thesis/Dissertation · Sun Jan 01 04:00:00 EST 1984

OSTI ID:6066499

This study was designed to evaluate ninety-second and fifteen-minute Technetium-DTPA (/sup 99m/Tc-DTPA) time-activity curves in acute unilateral renal artery stenosis (RAS). The /sup 99m/Tc-DTPA studies were compared to angiograms, PAH clearances (C/sup PAH/), and thirty-minute /sup 131/I-Hippuran renograms in eight dogs prior to and after RAS. Renal artery stenosis resulted in a reduction of the renal blood flow ranging from 32% to 68%, as measured by electromagnetic flow probe and C/sub PAH/. The mean arterial pressure increased 21 mmHg. Changes in the ninety-second /sup 99m/Tc-DTPA curve were identified by eight computer isolated curve parameters. The fifteen minute /sup 99m/Tc-DTPA curves were interpreted according to the same criteria used in analyzing the /sup 131/I-Hippuran renograms, specifically the time to maximum activity, ratios of peak activity, and time to return to baseline activity. Both the ninety-second and the fifteen-minute /sup 99m/Tc-DTPA studies were superior to the /sup 131/I-Hippuran renogram in assessing RAS. It is concluded that (1) /sup 99m/Tc-DTPA studies are superior to /sup 131/I-Hippuran renograms for detecting unilateral experimental RAS, and (2) /sup 99m/Tc-DTPA may be the radioisotope of choice for detection and follow-up of RAS.

• Research Organization: Medical Coll. of Ohio, Toledo (USA)
• OSTI ID: 6066499
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD FLOW
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
DTPA
DYNAMIC FUNCTION STUDIES
HIPPURAN
HOURS LIVING RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERFUSED ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RENOGRAPHY
SCINTISCANNING
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES