Technetium-99m DTPA renal flow studies in Goldblatt hypertension. [Dogs]

Journal Article · Thu Aug 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5313694

Nally, J V; Clarke, H S; Windham, J P; Grecos, G P; Gross, M L; Potvin, W J

Computer-assisted dynamic renal studies were performed on a group of 14 mongrel dogs before and after the induction of unilateral renal artery stenosis. Ninety-second technetium-99m diethylenetriaminepentaacetic acid ((/sup 99m/Tc)DTPA), 15-min (/sup 99m/Tc)DTPA, and 30-min iodine-131 orthoiodohippurate ((/sup 131/I)hippuran) time-activity curves were analyzed and correlated with reduction of renal blood flow as measured by electromagnetic flow probe and PAH clearance techniques. For blood flow reductions greater than 33%, the (/sup 99m/Tc)DTPA studies were judged diagnostic of unilateral renal artery stenosis in all cases, whereas the (/sup 131/I)hippuran time-activity curves were indicative of stenosis in only six of ten studies. Thus, in this model we find the computer-assisted 90-sec (/sup 99m/Tc)DTPA renal flow study to be superior to conventional (/sup 131/I)hippuran renography in the diagnosis of moderate-to-serve unilateral renal artery stenosis.

• Research Organization: Medical College of Ohio, Toledo
• OSTI ID: 5313694
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CONTRAST MEDIA
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
DTPA
DYNAMIC FUNCTION STUDIES
HIPPURAN
HOURS LIVING RADIOISOTOPES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SCINTISCANNING
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES