Reproductive and endocrinological features of male rats after treatment with cadmium chloride
Single subcutaneous injection of 1 or 5 mg cadmium chloride (CdCl/sub 2/) to adult male rats resulted in a significant reduction in the weights of the testis, epididymidis, vas deferens, ventral prostate and seminal vesicles. Sperm population in the vas deferens, caput and cauda epididymidis was severely reduced. Sexual drive and fertility were not changed 7 or 15 days after treatment with 1 mg CdCl/sub 2/; however, a loss of libido to total sterility were encountered in animals receiving 5 mg CdCl/sub 2/. The circulating testosterone and 5..cap alpha..-dihydrotestosterone were suppressed whereas androstenedione concentration remained unaltered. It appears that CdCl/sub 2/ not only affects spermatogenesis but also inhibits androgen production.
- Research Organization:
- Worcester Foundation for Experimental Biology, Shrewsbury, MA
- OSTI ID:
- 7282041
- Journal Information:
- Biol. Reprod.; (United States), Journal Name: Biol. Reprod.; (United States) Vol. 16:5; ISSN BIREB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANDROSTENEDIONE
ANIMALS
BIOLOGICAL EFFECTS
BODY
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
ENDOCRINE GLANDS
FERTILITY
GAMETES
GERM CELLS
GLANDS
GONADS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
INJECTION
INTAKE
KETONES
MALE GENITALS
MALES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROSTATE
QUANTITY RATIO
RATS
REPRODUCTION
RODENTS
SEX
SPERMATOZOA
STERILITY
STEROID HORMONES
STEROIDS
SUBCUTANEOUS INJECTION
TESTES
TESTOSTERONE
VERTEBRATES
WEIGHT