Modulation of microsomal membrane associated detoxication enzymes activity by methyl isocyanate (MIC) exposure

Journal Article · Thu Oct 31 23:00:00 EST 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01701133· OSTI ID:7278735

Mishra, A; Dwivedi, P D; Verma, A S; Mishra, J; Sinha, M; Dutta, K K; Ray, P K ^[1]

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1. Industrial Toxicology Research Centre, Lucknow (India)

In the industrial disaster at Bhopal, India in 1984 the leakage of 40 tons of methyl isocyanate (MIC) gas from a pesticide plant claimed over 2,500 lives and left an estimated population of 15,000 people suffering from a variety of ailments. MIC induced changes in respiratory functions including bronchial asthma, pulmonary oedema, necrosis of alveoli, hypersensitivity, pneumonities and incapacitated pulmonary functions. Reports have also indicated changes in the respiratory tract of animals as a result of exposure to MIC, the lung being the main target organ attacked by MIC. The authors earlier report of the high dose single exposure toxicity to methyl isocyanate leads to alterations in biotransformation enzymes and their isoenzymic pattern. Recently, a drastic decrease in Na{sup +}, K{sup +}, and Mg{sup ++} ATPase enzyme levels by repeated MIC exposure has been shown. The present study further explores the biochemical basis of MIC intoxication with reference to consecutive dose dependent toxicity in terms of alteration in phase 1 and phase 2 membrane bound detoxication enzymes.

• OSTI ID: 7278735
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States) Vol. 47:5; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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CELL CONSTITUENTS
CELL MEMBRANES
DETOXIFICATION
DEVELOPING COUNTRIES
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