Methyl isocyanate induced morphological changes in the seminiferous epithelium of rats maintained on normal or protein deficient diets
- Industrial Toxicology Research Centre, Lucknow (India)
- Mithila Univ., Darbhanga (India)
Methyl isocyanate (MIC), a pulmonary toxicant, is also reported to cause reproductive anomalies. MIC exposure decreased mating performance and fertility of mice and rats. However, the target cell type responsible for the decreased fertility could not be identified. Therefore, present studies are undertaken to analyze the action of MIC on spermatogenesis during one cycle of seminiferous epithelium. Protein deficiency, an important aspect of malnourishment, alter toxic potentials of various chemicals. About 90% of the affected people of Bhopal gas calamity belonged to low income group and were categorized as malnourished. Nutritional deficiency is also known to impair spermatogenesis and fertility. Therefore, experiments were designed to evaluate whether the protein deficiency influence the toxic potentials of MIC on testicular tissues.
- OSTI ID:
- 6849447
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States) Vol. 52:5; ISSN 0007-4861; ISSN BECTA6
- Country of Publication:
- United States
- Language:
- English
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