Isocyanates and respiratory disease: current status

Journal Article · Thu Dec 31 23:00:00 EST 1987 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700130304· OSTI ID:6936141

Musk, A W; Peters, J M; Wegman, D H

This paper reviews the known respiratory effects of isocyanates. There is good evidence to indicate that isocyanates: cause chemical bronchitis/pneumonitis; are potent pulmonary sensitizers capable of causing isocyanate asthma; cause nonspecific airways disease, including chronic bronchitis; can induce a general asthmatic state; and can cause hypersensitivity pneumonitis. Similar dose-response relationships are seen for both acute and chronic effects. There are plants operating in which exposures are well controlled and in which no respiratory effects can be detected. Suggestions are provided for preplacement assessment and periodic surveillance for workers exposed to these compounds.114 references.

• Research Organization: Sir Charles Gairdner Hospital, Nedlands (Australia)
• OSTI ID: 6936141
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 13:3; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
CARBONIC ACID DERIVATIVES
CYANATES
DISEASES
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
NITROGEN COMPOUNDS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PERSONNEL
POLLUTION
RESPIRATORY SYSTEM DISEASES
REVIEWS
TOXICITY