Influence of ozonation on the mutagenic activity of benzidine in water

Journal Article · Fri Nov 01 04:00:00 EST 1991 · Bulletin of Environmental Contamination and Toxicology; (United States)

DOI:https://doi.org/10.1007/BF01701143· OSTI ID:7278726

Fouillet, B; Chambon, P; Chambon, R ^[1]; Castegnaro, M ^[2]; Weill, N ^[3]

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1. Faculty of Pharmaceutical Sciences, Lyon (France)
2. International Agency for Research on Cancer, Lyon (France)
3. Hazleton, L'Arbresle (France)

In this study, benzidine was treated with ozone to determine the effectiveness of degradation and the genetic properties of ozone byproducts. Several types of ozonation were studied, partial ozonation, ozonation at about 99.9% and total ozonation. Disappearance of parent compounds and appearance of ozone byproducts were measured by high performance liquid chromatography (HPLC) coupled with spectrofluorimetry and UV spectrophotometry. A plate incorporation mutagenicity assay using Salmonella typhimurium strain was used to test the ozone byproducts in presence and in absence of metabolic activation system.

• OSTI ID: 7278726
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (United States), Journal Name: Bulletin of Environmental Contamination and Toxicology; (United States) Vol. 47:5; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AQUEOUS SOLUTIONS
AROMATICS
BACTERIA
BENZIDINE
CHEMICAL REACTIONS
DISPERSIONS
MICROORGANISMS
MIXTURES
MUTAGEN SCREENING
ORGANIC COMPOUNDS
OZONIZATION
SALMONELLA
SCREENING
SOLUTIONS
SPECTROPHOTOMETRY