Destruction of aromatic amines in laboratory wastes through oxidation with potassium permanganate/sulfuric acid into non-mutagenic derivatives
Nine aromatic amines, i.e., benzidine; o-tolidine; o-dianisidine; 3,3'-dichlorobenzidine; 4-aminobiphenyl; 1- and 2-naphthylamine; 4,4'-methylene bis(2-chloroaniline) and m-toluenediamine, were oxidized with potassium permanganate/sulfuric acid. Experimental conditions for complete degradation of these aromatic amines are described. The disappearance of the parent compound through oxidation was measured using HPLC coupled with UV spectrophotometry. The corresponding degradation products were found to be non-mutagenic to Salmonella typhimurium strains TA100, TA98 and TA97, both in the presence and absence of a rat liver S9 activation system. A collaborative study, involving 11 laboratories, has shown the applicability and the reproducibility of this degradation method.
- Research Organization:
- International Agency for Research on Cancer, Lyon Cedex, France
- OSTI ID:
- 5651412
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Vol. 46:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Structure-mutagenicity relationships of benzidine analogues
Genetic differences in metabolism of polycyclic aromatic carcinogens and aromatic amines by mouse liver microsomes. Detection by DNA binding of metabolites and by mutagenicity in histidine-dependent Salmonella typhimurium in vitro
Related Subjects
AMINES
MUTAGEN SCREENING
OXIDATION
ANILINE
BENZIDINE
BIPHENYL
CHEMICAL WASTES
INTERLABORATORY COMPARISONS
METABOLIC ACTIVATION
POTASSIUM PERMANGANATES
SALMONELLA TYPHIMURIUM
SULFURIC ACID
ULTRAVIOLET SPECTROMETERS
ALKALI METAL COMPOUNDS
AROMATICS
BACTERIA
CHEMICAL REACTIONS
HYDROCARBONS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
MANGANESE COMPOUNDS
MEASURING INSTRUMENTS
MICROORGANISMS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PERMANGANATES
POTASSIUM COMPOUNDS
SALMONELLA
SCREENING
SPECTROMETERS
TRANSITION ELEMENT COMPOUNDS
WASTES
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)