Practical methods of dose reduction to the bladder wall. [Radionuclide administration to patients]
The radiation dose to the bladder wall following the administration of radionuclides to patients can be reduced by a factor between 25 percent and 75 percent when the effective half-life for the radioactivity entering the urine is two hours or less. A significant but smaller reduction in dose to the gonads may also be achieved in situations where the major fraction of the administered activity is rapidly excreted in the urine. This reduction in dose is achieved by ensuring that the patient has between 50 and 150 ml of urine in his bladder when the radioactivity is injected, and is encouraged to void between one and two hours after the activity has been administered. The interrelationship of voiding schedule, effective half-life, initial urine volume, and demand urination has been analyzed in these studies. In addition, the significance of the rate of urine production and volume of urine in the bladder on the radiation dose to the bladder is demonstrated. (auth)
- Research Organization:
- Oak Ridge National Lab., Tenn. (USA)
- OSTI ID:
- 7267041
- Report Number(s):
- CONF-760444-9; TRN: 08-019655
- Resource Relation:
- Conference: Symposium on radiopharmaceutical dosimetry, Oak Ridge, TN, USA, 26 Apr 1976
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BLADDER
RADIATION DOSES
RADIONUCLIDE KINETICS
PATIENTS
RADIONUCLIDE ADMINISTRATION
URINE
EXCRETION
GONADS
NUCLEAR MEDICINE
RADIATION PROTECTION
RADIOPHARMACEUTICALS
TIME DEPENDENCE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CLEARANCE
DOSES
DRUGS
LABELLED COMPOUNDS
MEDICINE
ORGANS
RADIOACTIVE MATERIALS
URINARY TRACT
WASTES
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