Biodistribution and excretion of sup 125 I ioversol in conscious dogs

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Investigative Radiology; (USA)

DOI:https://doi.org/10.1097/00004424-198906001-00005· OSTI ID:5083597

Coveney, J R; Robbins, M S ^[1]

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1. Mallinckrodt, Inc., St. Louis, MO (USA)

Radiolabeled ioversol was injected intravenously into two male and two female beagle dogs (6.7 to 10.4 kg) at two dose levels each (0.2 and 1.0 g I/kg). Blood levels of radioactivity were monitored at 2, 5, 10, 20, 40, 60, 90, and 120 minutes and at one and two days. Urine and feces were collected in metabolism cages for two days, at the end of which the dogs were killed and organs or tissues (kidneys, liver, spleen, lungs, thyroid glands, heart, gonads, and muscle) were sampled. Radioactivity in tissues and excreta was assayed. Biexponential disappearance of radioactivity from blood was observed in three of four dogs at each dose level. Distribution half-lives averaged 2.5 to 3.5 minutes. Elimination half-lives averaged 51 to 54 minutes. Volumes of distribution averaged 25% to 27% of body weight. No organ retention was evident at 48 hours. Recovery of ioversol in urine and feces averaged 86% to 88% of the administered dose, of which all but a few percent was recovered in urine. On chromatographic assay, ioversol accounted for an average of 103% to 109% of radioiodine, suggesting, within the experimental limits of the assay, that ioversol is excreted unchanged. No dose-related differences were evident in any of these measures. The pharmacokinetics and biodistribution of ioversol are consistent with those of other extracellularly distributed iodinated contrast agents that are excreted by the kidney.

• OSTI ID: 5083597
• Journal Information: Investigative Radiology; (USA), Journal Name: Investigative Radiology; (USA); ISSN INVRA; ISSN 0020-9996
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
CHROMATOGRAPHY
CLEARANCE
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
TISSUE DISTRIBUTION
VERTEBRATES