Human major histocompatibility complex contains genes for the major heat shock protein HSP70

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.6.1968· OSTI ID:7266899

Sargent, C A; Dunham, I; Campbell, R D ^[1]; Trowsdale, J ^[2]

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1. Medical Research Council Immunochemistry Unit , Oxford (England)
2. Imperial Cancer Research Fund, London (England)

Little is known as to why a large number of human diseases are influenced by the major histocompatibility complex. In some cases, a direct involvement of the products of the polymorphic class I and class II, as well as the less variable products of the class III, genes has been proposed. During characterization of the class III region for the presence of additional loci, the authors have located a duplicated locus encoding the major heat shock protein HSP70 between the complement and tumor necrosis factor genes. The HSP70 loci are 12 kilobases apart and lie 92 kilobases telomeric of the C2 gene. As HSP70 proteins have been linked with a protective role during and after cellular stress, and HSP70 analogues are often presented as antigens in bacterial and protozoal infections, this finding may have major implications with regard to the major histocompatibility complex and associated diseases.

• OSTI ID: 7266899
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 86:6; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
BIOLOGICAL STRESS
DAYS LIVING RADIOISOTOPES
DISEASES
DNA HYBRIDIZATION
ETIOLOGY
GENES
HISTOCOMPATIBILITY COMPLEX
HUMAN POPULATIONS
HYBRIDIZATION
IMMUNE SYSTEM DISEASES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
POPULATIONS
PRIMATES
PROTEINS
RADIOISOTOPES
RFLPS
VERTEBRATES