Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

Journal Article · Tue Dec 01 04:00:00 EST 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.23.8535· OSTI ID:6408688

Carroll, M C; Katzman, P; Alicot, E M; Koller, B H; Geraghty, D E; Orr, H T; Strominger, J L; Spies, T

The tumor necrosis factor (TNF) ..cap alpha.. and ..beta.. gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

• Research Organization: Harvard Medical School, Boston, MA (USA)
• OSTI ID: 6408688
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:23; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIGENS
CARBOHYDRATES
DISEASES
ELECTROPHORESIS
ENZYMES
GENES
GENETIC MAPPING
GLUCOPROTEINS
GLYCOPROTEINS
HYBRIDIZATION
HYDROXYLASES
IMMUNOLOGY
MAMMALS
MAN
MAPPING
NECROSIS
NEOPLASMS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PRIMATES
PROTEINS
SACCHARIDES
VERTEBRATES