Mutagenic responses of some petroleum-base obscurants in the Ames test. Technical report, October 1986-December 1987
Technical Report
·
OSTI ID:7266203
In the Ames test, five petroleum fractions diesel fuel (DF) 25% distilled, DF with approximately 6% tetraethoxysilane, Jet-A, 75% bottoms product and Fog Oil, and methylene chloride extractions of combusted DF were evaluated for their mutagenic potential. The five fractions were dissolved in ethanol containing 1% Tween 80. One hundred milligrams of the residue from combusted DF was extracted with 25 mL of methylene chloride for 24 hr. After that time, the methylene chloride was replaced with acetone by evaporation. Each of five materials was tested in the four standard tester strains; TA97, TA98, TA100, and TA102, metabolically activated (aroclor 1254 induced rat liver S9) and nonactivated. Five concentrations, ranging upwards to the approximate level of cytotoxicity, of each material were tested, and the results in each case were confirmed with a similar nonconcurrent test. Positive results were not demonstrated in any of the materials tested.
- Research Organization:
- Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD (USA)
- OSTI ID:
- 7266203
- Report Number(s):
- AD-A-214201/6/XAB; CRDEC-TR--071
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETONE
AEROSOLS
ANTIMITOTIC DRUGS
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DIESEL FUELS
DISEASES
DISPERSIONS
DOCUMENT TYPES
DRUGS
EVAPORATION
HALIDES
HALOGEN COMPOUNDS
KETONES
METABOLIC ACTIVATION
MINERAL OILS
MUTAGEN SCREENING
NEOPLASMS
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOLOGY
PETROLEUM PRODUCTS
PHASE TRANSFORMATIONS
PROGRESS REPORT
RESIDUES
SCREENING
SMOKES
SOLS
TOXICITY
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETONE
AEROSOLS
ANTIMITOTIC DRUGS
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DIESEL FUELS
DISEASES
DISPERSIONS
DOCUMENT TYPES
DRUGS
EVAPORATION
HALIDES
HALOGEN COMPOUNDS
KETONES
METABOLIC ACTIVATION
MINERAL OILS
MUTAGEN SCREENING
NEOPLASMS
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOLOGY
PETROLEUM PRODUCTS
PHASE TRANSFORMATIONS
PROGRESS REPORT
RESIDUES
SCREENING
SMOKES
SOLS
TOXICITY