Responses of young calves to low doses of lead

Journal Article · Sun Aug 01 04:00:00 EDT 1976 · J. Dairy Sci.; (United States)

DOI:https://doi.org/10.3168/jds.S0022-0302(76)84389-5· OSTI ID:7263573

Lynch, G P; Jackson, E D; Kiddy, C A; Smith, D F

Twenty calves, week-old male Holsteins, 42.8 kg body weight, were assigned to four treatments by oral dose 0, 1.5, 3.0, and 6.0 mg lead carbonate/kg body weight given three times weekly until calf fetal hemoglobin had been converted to 100 percent adult hemoglobin for 2 consecutive weeks. Analyses were for the first 7 weeks when data were complete. Variables included lead in blood, body weight changes, erythrocyte delta-aminolevulinic acid dehydrase activity, packed cell volume, hemoglobin, conversion of fetal to adult hemoglobin, and erythrocyte 2,3-diphosphoglyceric acid. Early changes due to lead treatment were inhibition of delta-aminolevulinic acid dehydrase at all doses and increased loss of hemoglobin at 3.0 and 6.0 mg doses. Growth rate was not impaired seriously by lead treatment. The 2,3-diphosphoglyceric acid in erythrocytes reached peak value at 3 to 4 weeks of age and then decreased with age, but 2,3-diphosphoglyceric acid of the treated calves was not changed by the low lead dosing. Low lead dosing will induce early metabolic changes in the young calf prior to inhibition of growth.

• Research Organization: Department of Agriculture, Beltsville, MD
• OSTI ID: 7263573
• Journal Information: J. Dairy Sci.; (United States), Journal Name: J. Dairy Sci.; (United States) Vol. 59:8; ISSN JDSCA
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALVES
CARBON COMPOUNDS
CARBONATES
CARBOXYLIC ACIDS
CATTLE
DOMESTIC ANIMALS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ERYTHROCYTES
GLOBIN
GROWTH
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LEAD
LEAD CARBONATES
LEAD COMPOUNDS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RUMINANTS
VERTEBRATES