Comparative toxicity to weanling and adult rats of lead acetate in water

Conference · Mon Jun 01 04:00:00 EDT 1981 · Trace Subst. Environ. Health; (United States)

OSTI ID:6428418

Rader, J I; Celesk, E M; Peeler, J T; Mahaffey, K R

The relative toxicity of lead acetate provided at uniform exposure levels (..mu..g/ml in water) or at uniform dosages (mg/kg body wt) was studied in groups of weanling and adult rats. Free erythrocyte protoporphyrins, urinary delta-aminolevulinic acid and blood Pb levels were measured. The accumulation of Pb in brain, kidney and bone (femur) was measured to determine the effect of age on tissue distribution and retention of Pb. Under conditions in which both weanling and adult rats were exposed to the same concentrations of Pb in drinking water, toxic effects of the metal were more pronounced in weanlings than in adults. This was due in part to higher doses of Pb per kg of body weight ingested by the young animals under these conditions. Under conditions of uniform dosage, retention of Pb (as % of ingested dose) in brain tissue and femur was significantly higher in weanling than adult animals.

• Research Organization: Food and Drug Administration, Cincinnati, OH
• OSTI ID: 6428418
• Report Number(s): CONF-8106251-
• Conference Information: Journal Name: Trace Subst. Environ. Health; (United States) Journal Volume: 15
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ADULTS
AGE DEPENDENCE
AGE GROUPS
ANIMALS
CARBOXYLIC ACID SALTS
COMPARATIVE EVALUATIONS
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
ELEMENTS
HYDROGEN COMPOUNDS
LEAD
LEAD COMPOUNDS
MAMMALS
METABOLISM
METALS
NEONATES
OXYGEN COMPOUNDS
RATS
RETENTION
RODENTS
SENSITIVITY
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
WATER