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Fast neutron beam radiotherapy of glioblastoma multiforme

Conference · · Am. J. Roentgenol.; (United States)
OSTI ID:7263502
; ; ; ;
Twenty-one patients with glioblastoma multiforme were treated with fast neutron beam irradiation of the whole brain. Therapy was well tolerated up to calculated doses of 1,850 rad/sub n + gamma/ in 12--18 increments over 6 weeks. The survival rate 6 months after initiation of treatment was 62 percent, not significantly different from conventional photon therapy; average post-treatment survival appears to be shortened compared to photon therapy. No improvement or prolonged maintenance of existing neurologic function was observed. Autopsy findings in seven patients showed replacement of tumor by coagulative necrosis persisting at least 16 months post-treatment, paucity of tumor cells with infrequent mitoses, and suppression of macrophage response. These findings differ from those in conventionally irradiated patients. No treatment-related changes were documented by conventional gross and histologic studies of the irradiated brains distant from the tumors. Thus the deaths of patients in this study appear to be related to unexplained causes other than progressive growth of tumor.
Research Organization:
Univ. of Washington, Seattle
OSTI ID:
7263502
Conference Information:
Journal Name: Am. J. Roentgenol.; (United States) Journal Volume: 127:2
Country of Publication:
United States
Language:
English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AUTOPSY
BARYONS
BODY
BRAIN
CELL DIVISION
CENTRAL NERVOUS SYSTEM
CONNECTIVE TISSUE CELLS
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
HADRONS
MACROPHAGES
MASSLESS PARTICLES
MEDICINE
MITOSIS
NECROSIS
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PHAGOCYTES
PHOTONS
RADIOLOGY
RADIOTHERAPY
SOMATIC CELLS
SURVIVAL CURVES
THERAPY
TUMOR CELLS