Halogenated pyrimidines as radiosensitizers in the treatment of glioblastoma multiforme
Sixty patients with high-grade gliomas (including 50 patients with glioblastoma multiforme) were entered on four sequential Phase I trials combining continuous intravenous infusions of halogenated pyrimidines and high-dose brain irradiation. Patients received two 14-day infusions of bromodeoxyuridine (BUdR) or iododeoxyuridine (IUdR) during the initial wide field and later reduced field radiation treatment (total radiation dose 65-70 Gy). All patients were followed a minimum of 6 months or until death. The actuarial median survival was 13 months for the entire group, with an 18-month survival of 24%. No significant survival differences were observed based on BUdR versus IUdR, 12-h versus 24-h infusion schedule, degree of surgical resection, or sex. Good performance status and age under 50 years were significant favorable prognostic factors. Of interest, the 48 patients who completed planned treatment had a 14-month median survival, with a 30% 18-month survival. These survival observations are at least comparable to other combined modality trials in patients with glioblastoma multiforme. Ongoing and planned clinical trials using the halogenated pyrimidine analogs as radiosensitizers in patients with glioblastoma multiforme are discussed.
- Research Organization:
- National Cancer Institute, Bethesda, MD
- OSTI ID:
- 5849649
- Journal Information:
- Am. J. Clin. Oncol.; (United States), Journal Name: Am. J. Clin. Oncol.; (United States) Vol. 10:5; ISSN AJCOD
- Country of Publication:
- United States
- Language:
- English
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550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIMETABOLITES
AZINES
BODY
BRAIN
BROMOURACILS
BUDR
CENTRAL NERVOUS SYSTEM
COMBINED THERAPY
DISEASES
DRUGS
GLIOMAS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
NEOPLASMS
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PYRIMIDINES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RIBOSIDES
SURVIVAL CURVES
THERAPY
URACILS