Fast neutron radiation therapy for glioblastoma multiforme. Results of an RTOG study

Journal Article · Thu Dec 01 04:00:00 EST 1983 · Am. J. Clin. Oncol.; (United States)

DOI:https://doi.org/10.1097/00000421-198312000-00009· OSTI ID:5075362

Griffin, T W; Davis, R; Laramore, G; Hendrickson, F; Rodrigues-Antunez, A; Hussey, D; Nelson, J

Between January 1977 and September 1980, 166 patients were entered on a RTOG protocol comparing neutron-boost radiotherapy with standard treatment for patients with glioblastomas. Eighty-three patients were randomized to receive a neutron boost and 83 to receive a photon boost after 50 Gy photon, whole-brain irradiation. Of these, six were ineligible and two were cancelled, leaving 158 patients available for analysis. The median survival for the neutron-boost group was 9.8 months, compared to 8.6 months for the photon-boost group. The difference is not statistically significant. Autopsies revealed actively growing persistent tumor in all photon-treated patients compared to no evidence of actively growing tumor in the majority of neutron-treated patients.

• Research Organization: Univ. of Washington Hospital, Seattle
• OSTI ID: 5075362
• Journal Information: Am. J. Clin. Oncol.; (United States), Journal Name: Am. J. Clin. Oncol.; (United States) Vol. 6:6; ISSN AJCOD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ASTROCYTOMAS
BARYONS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DISEASES
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
GLIOMAS
HADRONS
MASSLESS PARTICLES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
ORGANS
PATIENTS
PHOTONS
RADIOLOGY
RADIOTHERAPY
SURVIVAL TIME
THERAPY