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Altered collagen metabolism in radiation-induced interstitial pulmonary fibrosis

Journal Article · · Chest (Chicago); (United States)
; ; ;
In the present study, we review the relationship of collagen metabolism, morphology, and physiologic function to the development of radiation-induced fibrosis as determined by work in our laboratory. Included are observations made on beagle dogs and Syrian hamsters which received single, short-term inhalation exposures to either alpha- or beta-emitting radionuclides. Comparisons are also made with results of the external irradiation of Syrian hamster lungs.
Research Organization:
Inhalation Toxicology Research Inst., Albuquerque, NM
OSTI ID:
7254579
Journal Information:
Chest (Chicago); (United States), Journal Name: Chest (Chicago); (United States) Vol. 69:2; ISSN CHETB
Country of Publication:
United States
Language:
English

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Related Subjects

560152 -- Radiation Effects on Animals-- Animals
560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA PARTICLES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CERIUM 144
CERIUM ISOTOPES
CHALCOGENIDES
CHARGED PARTICLES
COBALT 60
COBALT ISOTOPES
COLLAGEN
CORRELATIONS
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
EXTERNAL IRRADIATION
FIBROSIS
GAMMA RADIATION
HAMSTERS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INHALATION
INJURIES
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MAMMALS
METABOLISM
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PLUTONIUM 238
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
STRONTIUM 90
STRONTIUM ISOTOPES
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YTTRIUM 90
YTTRIUM 99
YTTRIUM ISOTOPES