Pulmonary collagen metabolism after lung injury from inhaled /sup 90/Y in fused clay particles

Journal Article · Sun Aug 01 04:00:00 EDT 1976 · Exp. Mol. Pathol.; (United States)

DOI:https://doi.org/10.1016/0014-4800(76)90018-6· OSTI ID:7292239

Pickrell, J A; Harris, D V; Benjamin, S A; Cuddihy, R G; Pfleger, R C; Mauderly, J L

Pulmonary fibrosis was studied in Syrian hamsters exposed by inhalation to an aerosol of /sup 90/Y in fused montmorillonite clay particles. Control hamsters were exposed to an aerosol of fused clay containing stable zirconium. Animals with cumulative radiation doses to lung of 2000 to 14,000 rad were sacrificed between 14 and 169 days after exposure. Controls were sacrificed at similar times. One day before sacrifice, the animals were injected with (/sup 14/C)-proline to label pulmonary collagen. When compared with controls, fractional incorporation of (/sup 14/C)-proline into native collagen increased as early as 14 days after /sup 90/Y exposure. This collagen synthesis continued to increase until about 126 days after exposure when fractional incorporation in irradiated animals was 175 percent of the mean control values. It remained at this level through 169 days. Collagen degradation, measured by ultrafilterable hydroxyproline peptides, increased similarly by 14 days after exposure, but later returned to values similar to those for control animals. By 55 days after exposure, when fibrosis was observed histologically, pulmonary native collagen was increased in irradiated animals as compared to control animals. Static lung compliance in irradiated hamsters, a measure of expansibility of the lung, was decreased 14 through 55 days after exposure. Later, compliance became indistinguishable from that of control animals when this parameter increased in both groups. This study demonstrated that pulmonary injury from beta irradiation delivered within a 2-week period stimulated both synthesis and degradation of collagen which led to collagen accumulation and scarring by 2 months after exposure. Continued radiation was not necessary to sustain this particular response of the lung to injury.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• OSTI ID: 7292239
• Journal Information: Exp. Mol. Pathol.; (United States), Journal Name: Exp. Mol. Pathol.; (United States) Vol. 25:1; ISSN EXMPA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON 14 COMPOUNDS
CLAYS
COLLAGEN
DAYS LIVING RADIOISOTOPES
HAMSTERS
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
METABOLISM
MINERALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SCLEROPROTEINS
TRACER TECHNIQUES
VERTEBRATES
YTTRIUM 90
YTTRIUM ISOTOPES