Radiation-induced pulmonary fibrosis: study of changes in collagen constituents in different lung regions of beagle dogs after inhalation of beta-emitting radionuclides. [/sup 90/Y, /sup 91/Y, /sup 144/Ce, and /sup 90/Sr]

Journal Article · Mon May 01 04:00:00 EDT 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574895· OSTI ID:6879965

Pickrell, J; Schnizlein, C T; Hahn, F F; Snipes, M B; Jones, R K

Pulmonary collagen turnover (synthesis, degradation, and accumulation) was studied in 40 dogs injured by inhalation exposure to /sup 90/Y (T/sub /sup 1///sub 2//eff 2.6 days, anti E = 0.9 MeV), /sup 91/Y (50 days, 0.59 MeV), /sup 144/Ce (170 days, 1.29 MeV), or /sup 90/Sr (370 days, 1.13 MeV) in fused aluminosilicate particles. Cerium-144 and /sup 90/Sr in fused particles produced more uniform patterns of pulmonary damage than did /sup 90/Y or /sup 91/Y in fused particles. Fibrosis was more severe in the intermediate than in the peripheral or hilar regions of the lungs of dogs exposed to /sup 90/Y in fused particles. That observation was consistent with the relatively greater radiation dose delivered to the peribronchiolar region during the early clearance of /sup 90/Y. Collagen synthesis and degradation responses in the peripheral and hilar regions of animals exposed to /sup 91/Y and in the intermediate area of /sup 90/Sr indicated the presence of previously formed scars. The degradation responses of the intermediate region of older animals exposed to /sup 144/Ce indicated the presence of an early stage of lung injury, that is, actively forming scars. The results in dogs support our earlier suggestion (based upon data in Syrian hamsters exposed to alpha and beta-gamma radiation) that the pathogenesis of pulmonary fibrosis after these single inhalations of radioactive aerosols may include (a) initial collagen degradation, followed by (b) increased synthesis and increased accumulation of collagen, and then (c) a return to a more normal rate of synthesis and possibly degradation, retaining, however, significant fibrosis. High radiation dose rates (during early times) after exposure may be important in eliciting sustained pulmonary fibrosis; however, the fact that /sup 90/Sr, which had the lowest initial dose rate, produced scarring at approximately the same times (6 to 16 months) as the other radionuclides indicates that total radiation dose is also imporant.

• Research Organization: Inhalation Toxicology Research Inst., Albuquerque, NM
• OSTI ID: 6879965
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 74:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CERIUM 144
CERIUM ISOTOPES
CLEARANCE
COLLAGEN
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
DOSE RATES
DOSES
EVEN-EVEN NUCLEI
EXCRETION
FIBROSIS
HOURS LIVING RADIOISOTOPES
INHALATION
INJURIES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
METABOLISM
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROTEINS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOSENSITIVITY EFFECTS
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
SCLEROPROTEINS
STRONTIUM 90
STRONTIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
YTTRIUM 90
YTTRIUM 91
YTTRIUM ISOTOPES