Structure and chromosomal localization of the human renal kallikrein gene
Journal Article
·
· Biochemistry; (United States)
Glandular kallikreins are a family of proteases encoded by a variable number of genes in different mammalian species. In all species examined, however, one particular kallikrein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. This kallikrein is found in the kidney, pancreas, and salivary gland, showing a unique pattern of tissue-specific expression relative to other members of the family. The authors have isolated a genomic clone carrying the human renal kallikrein gene and compared the nucleotide sequence of its promoter region with those of the mouse renal kallikrein gene and another mouse kallikrein gene expressed in a distinct cell type. They find four sequence elements conserved between renal kallikrein genes from the two species. They have also shown that the human gene is localized to 19q13, a position analogous to that of the kallikrein gene family on mouse chromosome 7.
- Research Organization:
- Univ. of Melbourne, Parkville (Australia)
- OSTI ID:
- 7253331
- Journal Information:
- Biochemistry; (United States), Journal Name: Biochemistry; (United States) Vol. 27:9; ISSN BICHA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
BLOOD COAGULATION FACTORS
BODY
COAGULANTS
DAYS LIVING RADIOISOTOPES
DNA SEQUENCING
DRUGS
ELECTROPHORESIS
ENZYMES
GENES
GENETIC MAPPING
GLANDS
HEMATOLOGIC AGENTS
HYDROLASES
ISOTOPES
KIDNEYS
KININOGENIN
LIGHT NUCLEI
MAMMALS
MAN
MAPPING
MICE
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SALIVARY GLANDS
SERINE PROTEINASES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ATP
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EVOLUTION
BLOOD COAGULATION FACTORS
BODY
COAGULANTS
DAYS LIVING RADIOISOTOPES
DNA SEQUENCING
DRUGS
ELECTROPHORESIS
ENZYMES
GENES
GENETIC MAPPING
GLANDS
HEMATOLOGIC AGENTS
HYDROLASES
ISOTOPES
KIDNEYS
KININOGENIN
LIGHT NUCLEI
MAMMALS
MAN
MAPPING
MICE
NUCLEI
NUCLEOTIDES
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SALIVARY GLANDS
SERINE PROTEINASES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES