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Clinical results of stereotactic hellium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

Conference ·
OSTI ID:7243614
; ; ; ; ; ;
The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed at Lawrence Berkeley Laboratory (LBL) for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory. 11 refs.
Research Organization:
Lawrence Berkeley Lab., CA (USA)
Sponsoring Organization:
DOE/ER
DOE Contract Number:
AC03-76SF00098
OSTI ID:
7243614
Report Number(s):
LBL-28249; CONF-8906298--1; ON: DE90008465
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACROMEGALY
ANIMALS
BEAMS
BODY
CHARGED PARTICLES
CUSHING SYNDROME
DATA
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HAZARDS
HEALTH HAZARDS
HEAVY IONS
HELIUM IONS
HORMONES
INFORMATION
INJURIES
INTERNAL IRRADIATION
IONS
IRRADIATION
LAWRENCE BERKELEY LABORATORY
MAMMALS
MAN
MEDICINE
METABOLIC DISEASES
MINIMIZATION
NATIONAL ORGANIZATIONS
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PARTICLE BEAMS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
PRIMATES
RADIOLOGY
RADIOTHERAPY
SURGERY
THERAPEUTIC USES
THERAPY
US AEC
US DOE
US ERDA
US ORGANIZATIONS
USES
VERTEBRATES