Delayed sequelae of pituitary irradiation
Journal Article
·
· Hum. Pathol.; (United States)
Since 1958, 781 patients at Lawrence Berkeley Laboratory have received helium-particle stereotactic radiosurgery to the adenohypophysis. Autopsy findings in 15 of these patients are reported. Ten patients received pituitary radiation (average dose, 116 Gy in six fractions) for progressive neovascularization retinopathy due to diabetes mellitus. Evidence of a time-dependent course of progressive fibrosis in their pituitary glands was found. Five patients were treated for eosinophilic adenomas. Although they had lower average doses of radiation (56 Gy in six fractions), their pituitary glands showed cystic cavitation of the adenomas. The adenomas thus appeared more radiosensitive than the normal pars anterior, which, in turn, was more radiosensitive than the adjacent neurohypophysis. No significant radiation changes were found in the surrounding brain or cranial nerves. The endocrine organs under pituitary control showed varying degrees of atrophy, and clinical tests revealed progressive hypofunction. It was concluded that charged-particle therapy produced a sharply delineated focal ral tests revealed progressive hypofunction. It was concluded that charged-particle therapy produced a sharply delineated focal radiation lesion confined to the pituitary gland but did not cause injury to the critical structures of the surrounding central nervous system.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 6500400
- Journal Information:
- Hum. Pathol.; (United States), Journal Name: Hum. Pathol.; (United States) Vol. 15:1; ISSN HPCQA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Profiling of adrenocorticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC–ESI-MS–MS
Clinical results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory
Radiotherapy of nonfunctional adenomas of the pituitary gland. Results with long-term follow-up
Journal Article
·
Wed Jun 17 20:00:00 EDT 2015
· Analytical and Bioanalytical Chemistry
·
OSTI ID:1186003
Clinical results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory
Conference
·
Thu Nov 30 23:00:00 EST 1989
·
OSTI ID:7146296
Radiotherapy of nonfunctional adenomas of the pituitary gland. Results with long-term follow-up
Journal Article
·
Thu Jun 15 00:00:00 EDT 1989
· Cancer (Philadelphia); (United States)
·
OSTI ID:5717750
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ENDOCRINE GLANDS
GLANDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PITUITARY GLAND
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ENDOCRINE GLANDS
GLANDS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PITUITARY GLAND
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
THERAPY