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Clinical results of stereotactic helium-ion radiosurgery of the pituitary gland at Lawrence Berkeley Laboratory

Conference ·
OSTI ID:7146296
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The first therapeutic clinical trial using accelerated heavy-charged particles in humans was performed for the treatment of various endocrine and metabolic disorders of the pituitary gland, and as suppressive therapy for adenohypophyseal hormone-responsive carcinomas and diabetic retinopathy. Since then, over 800 patients have received stereotactically-directed plateau-beam heavy-charged particle pituitary irradiation at this institution. In acromegaly, Cushing's disease, Nelson's syndrome and prolactin-secreting tumors, the therapeutic goal in the 433 patients treated has been to destroy or inhibit the growth of the pituitary tumor and control hormonal hypersecretion, while preserving a functional rim of tissue with normal hormone-secreting capacity, and minimizing neurologic injury. An additional group of 34 patients was treated for nonsecreting chromophobe adenomas. This paper discusses the methods and results of these treatments. 11 refs.

Research Organization:
Lawrence Berkeley Lab., CA (USA)
Sponsoring Organization:
DOE/ER
DOE Contract Number:
AC03-76SF00098
OSTI ID:
7146296
Report Number(s):
LBL-28253; CONF-8905227--6; ON: DE90008467
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACROMEGALY
ANIMALS
BODY
CARCINOMAS
CHARGED PARTICLES
CUSHING SYNDROME
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HELIUM IONS
HORMONES
INTERNAL IRRADIATION
IONS
IRRADIATION
LAWRENCE BERKELEY LABORATORY
MAMMALS
MAN
MEDICINE
METABOLIC DISEASES
MINIMIZATION
NATIONAL ORGANIZATIONS
NEOPLASMS
NEUROLOGY
NUCLEAR MEDICINE
ORGANS
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
PRIMATES
RADIOLOGY
RADIOTHERAPY
SURGERY
THERAPEUTIC USES
THERAPY
US AEC
US DOE
US ERDA
US ORGANIZATIONS
USES
VERTEBRATES