Assessment of toxicity of automotive metallic emissions. Volume I. Final report
Technical Report
·
OSTI ID:7240259
Lead salts are an emission product from mobile (or automotive) emission sources due to the addition of tetraethyl lead to gasoline. Because of known toxic properties of lead salts, it has been proposed that alkyl manganese compounds be substituted as a fuel additive for tetraethyl lead. With the introduction of platinum and palladium in the catalytic converters of 1975-model year vehicles, it is of concern to determine the quantities of platinum and palladium metal and salts which will be in emission products and the biological effects of these compounds on mammalian tissues. Various parameters of toxicity have been studied for salts of manganese, lead, palladium, and platinum. Acute toxicities (LD-50 doses) are reported for both intraperitoneal injection and oral administration. Concentrations of metallic ions following dietary administration are reported, as are effects on weights of five organs (liver, kidney, spleen, heart, testes). Also following dietary administration, hepatic microsomes were isolated and the following parameters related to in vitro drug metabolism were measured, yield of microsomal protein/g liver, in vitro activities of aniline hydroxylase and aminopyrine demethylase, content of cytochromes P-450 and b5/mg microsomal protein. Development of a rapid and convenient method for the analysis of ribosomal RNA in studies of RNA synthesis is reported. (GRA)
- Research Organization:
- North Carolina Univ., Chapel Hill (USA). School of Medicine
- OSTI ID:
- 7240259
- Report Number(s):
- PB-251231
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AUTOMOBILES
BIOLOGICAL EFFECTS
DOSES
ELEMENTS
EXHAUST GASES
GASEOUS WASTES
HAZARDS
HEALTH HAZARDS
LEAD COMPOUNDS
MANGANESE COMPOUNDS
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Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AUTOMOBILES
BIOLOGICAL EFFECTS
DOSES
ELEMENTS
EXHAUST GASES
GASEOUS WASTES
HAZARDS
HEALTH HAZARDS
LEAD COMPOUNDS
MANGANESE COMPOUNDS
METALS
PALLADIUM COMPOUNDS
PLATINUM COMPOUNDS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VEHICLES
WASTES