Effects of special blue fluorescent light on hepatic mixed-function oxidase activity in the rat
Journal Article
·
· Pediatr. Pharmacol.; (United States)
OSTI ID:6562537
Phototherapy has been widely used in the treatment of neonatal hyperbilirubinemia. Recent reports, however, have indicated that fluorescent light may be toxic and mutagenic to mammalian cells. these findings suggest possible long-term side effects with the use of phototherapy. This study was undertaken to determine the effects of phototherapy on hepatic microsomal enzyme activity. The exposure of Sprague-Dawley and Gunn rats to special blue fluorescent light at an average irradiance of 1,200 microW/cm2 resulted in no significant changes in liver microsomal enzyme activity for aniline hydroxylase, p-nitroanisole-O-demethylase, ethylmorphine-N-demethylase, cytochrome c reductase or the quantity of cytochrome P-450. A significant decrease in aniline hydroxylase and p-nitroanisole-O-demethylase activity was observed when liver microsomes were exposed in vitro to special blue fluorescent light. Photoactivated bilirubin did not effect the activity of the mixed-function oxidase enzymes measured under the conditions of this study.
- Research Organization:
- The Ohio State University Department of Veterinary Physiology, Columbus
- OSTI ID:
- 6562537
- Journal Information:
- Pediatr. Pharmacol.; (United States), Journal Name: Pediatr. Pharmacol.; (United States) Vol. 1:4; ISSN PPHAD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550300 -- Cytology
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZOLES
BILIRUBIN
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
DIGESTIVE SYSTEM
ENZYME ACTIVITY
FLUORESCENT LAMPS
GLANDS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INHIBITION
JAUNDICE
LIGHT BULBS
LIVER
MAMMALS
MEDICINE
MICROSOMES
MUTAGENESIS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
PATHOLOGICAL CHANGES
PHOTOSENSITIVITY
PIGMENTS
PYRROLES
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SENSITIVITY
SYMPTOMS
THERAPY
TOXICITY
VERTEBRATES
550300 -- Cytology
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZOLES
BILIRUBIN
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
DIGESTIVE SYSTEM
ENZYME ACTIVITY
FLUORESCENT LAMPS
GLANDS
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INHIBITION
JAUNDICE
LIGHT BULBS
LIVER
MAMMALS
MEDICINE
MICROSOMES
MUTAGENESIS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
PATHOLOGICAL CHANGES
PHOTOSENSITIVITY
PIGMENTS
PYRROLES
RADIOLOGY
RADIOTHERAPY
RATS
RODENTS
SENSITIVITY
SYMPTOMS
THERAPY
TOXICITY
VERTEBRATES