Induction of hepatic microsomal mixed-function oxidase activities in the mouse by mirex, 3,4,5,3',4',5'-Hexachlorobiphenyl, and equimolar dosages of both

Journal Article · Mon Nov 30 23:00:00 EST 1981 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(81)90216-4· OSTI ID:5841299

Peppriell, J

At low oral dosages (15 ..mu..mole/kg) neither mirex nor 3,4,5,3',4',5'- hexachlorobiphenyl was found to significantly elevate hepatic microsomal cytochrome(s) P-450 in the mouse, 7 days post-treatment. The associated drug metabolic activities, aminopyrine-N-demethylase, p-nitroanisole-O-demethylase, and aniline hydroxlase, were also not significantly elevated above control levels. However, aminopyrine-N-demethylase and p-nitroanisole-O-demethylase activities were significantly elevated by a 1:1 molar combination of the two compounds (''Both''), administered at a total molar concentration (15 ..mu..mole/kg) equal to that of either of the two constituents. Concomitant administration of the molar sum of Mirex and the hexachlorobiphenyl significantly elevated all three metabolic activities and cytochrome(s) P-450 concentration. The relatively greater effect of ''Both'' in elevating these activities may be due to the simultaneous elevation of cytochromes P-450 and P-448.

• Research Organization: State Univ. of New York, Buffalo
• OSTI ID: 5841299
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 26:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
DIGESTIVE SYSTEM
ENZYME ACTIVITY
GLANDS
HYDROXY COMPOUNDS
INDUCTION
LIVER
MAMMALS
MICE
MICROSOMES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PHENOLS
RODENTS
VERTEBRATES