Effects of platinum and palladium salts on parameters of drug metabolism in rat liver

Journal Article · Thu Jul 01 04:00:00 EDT 1976 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397609529409· OSTI ID:7212791

Holbrook, Jr, D J ^[1]; Washington, M E; Leake, H B; Brubaker, P E

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1. Univ. of North Carolina, Chapel Hill

The effects of various salts of platinum or palladium were determined on the parameters of the microsomal mixed-function oxidase system from rat liver. The intraperitoneal injection of PtCl/sub 4/ or Pd(NO/sub 3/)/sub 2/ increased the hexobarbital-induced sleeping time in vivo and generally decreased the aminopyrine demethylase and the content of cytochrome P-450 in isolated hepatic microsomes. The dietary administration of various salts of platinum or palladium for 1 wk generally decreased or had no effect on the parameters of drug metabolism by isolated microsomes and after 4 or more wk generally had no effect on, or increased, the parameters. The addition of 0.15 to 0.2 mM PtCl/sub 4/ or 0.2 to 0.3 mM Pd(NO/sub 3/)/sub 2/ to the incubation medium (containing 5 mM MgCl/sub 2/) inhibited the aminopyrine demethylase of isolated hepatic microsomes by 50 percent.

• OSTI ID: 7212791
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 1:6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
DIET
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
ENZYMES
GLANDS
HYPNOTICS AND SEDATIVES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LIVER
MAMMALS
METABOLISM
METALS
MICROSOMES
ORGANOIDS
ORGANS
OXIDASES
OXIDOREDUCTASES
PALLADIUM
PLATINUM
PLATINUM METALS
RATS
RODENTS
SLEEP
TRANSITION ELEMENTS
VERTEBRATES