Radiosensitization of mammalian cells by diamide

Technical Report · Thu Jan 01 04:00:00 EST 1976

OSTI ID:7223070

Vos, O; Grant, G A; Budke, L

The effect of diamide on the radiosensitivity of T-cells was investigated under oxic and anoxic conditions. The compound was found to sensitize the cells under both conditions. Under oxic conditions, exposure for 10 min before and during irradiation to 0.1, 0.5, and 1.0 mm diamide produced dose-modifying factors of 0.81, 0.60, and 0.55, respectively. Under anoxic conditions exposure for 10 min before and during irradiation to 0.5 mm produced a dose-modifying factor of 0.34. When the cells in oxic conditions were exposed for just 20 min before irradiation, the sensitizing effect was smaller, but some sensitization effect was still apparent after a 120 min interval between diamide treatment and irradiation. Diamide also sensitized the cells after irradiation but this effect was less than when it was present during irradiation. It is proposed that sensitization is due to lack of capacity for repair of radicals by hydrogen transfer and biochemical repair processes. (Author) (GRA)

• Research Organization: Rijksverdedigingsorganisatie TNO, Rijswijk (Netherlands). Medisch Biologisch Lab. TNO
• OSTI ID: 7223070
• Report Number(s): N-76-31889; MBL-1976-1; TDCK-67285
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANOXIA
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
LEUKOCYTES
LYMPHOCYTES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADICALS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SOMATIC CELLS