Involvement of T- and B-lymphocytes in the immune response to the protein exotoxin and the lipopolysaccharide antigens of Vibrio cholerae
Journal Article
·
· Ann. N.Y. Acad. Sci.; (United States)
The immune response at the level of individual immunocytes to the somatic lipopolysaccharide antigen derived from whole Vibrio cholerae and to the purified protein exotoxin from this organism were studied in terms of the role of T- and B-lymphocytes. By adoptive cell transfer studies with irradiated recipient mice, it was shown that normal spleen cells from normal syngeneic mice could readily transfer the capability of responding to both types of cholera antigens. However, when the spleen cells were depleted of T-cells with anti-theta serum and complement, antibody responsiveness to the LPS antigen, but not the exotoxin, could be achieved in recipients. Furthermore, by appropriate transfer of either bone marrow, thymus, or thymus-marrow cell mixtures to irradiated mice, it was shown that the response to the cholera somatic antigen was relatively independent of thymus cells, whereas the response to exotoxin required ''helper'' T-cells.
- Research Organization:
- Albert Einstein Medical Center, Philadelphia
- OSTI ID:
- 7221862
- Journal Information:
- Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 249; ISSN ANYAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300* -- Cytology
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CHOLERA
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNE REACTIONS
INFECTIOUS DISEASES
LEUKOCYTES
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHOCYTES
MAMMALS
MICE
MICROORGANISMS
ORGANIC COMPOUNDS
POLYSACCHARIDES
PROTEINS
RADIATION EFFECTS
RODENTS
SACCHARIDES
SOMATIC CELLS
SPLEEN CELLS
TOXIC MATERIALS
TOXINS
VERTEBRATES
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CHOLERA
CONNECTIVE TISSUE CELLS
DISEASES
IMMUNE REACTIONS
INFECTIOUS DISEASES
LEUKOCYTES
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHOCYTES
MAMMALS
MICE
MICROORGANISMS
ORGANIC COMPOUNDS
POLYSACCHARIDES
PROTEINS
RADIATION EFFECTS
RODENTS
SACCHARIDES
SOMATIC CELLS
SPLEEN CELLS
TOXIC MATERIALS
TOXINS
VERTEBRATES