Reversal of experimental diabetes by fetal rat pancreas. I. Survival and function of fetal rat pancreas frozen to -196/sup 0/C. [Growth and insulin synthesis in transplanted fetal pancreas preserved by freezing]

Conference · Tue Mar 01 00:00:00 EST 1977 · Transplant. Proc.; (United States)

OSTI ID:7220763

Kemp, J A; Mazur, P; Mullen, Y; Miller, R H; Clark, W; Brown, J

Pancreatic rudiments from fetal rats were frozen and held at -196/sup 0/C for approximately 9 to 13 weeks and then transplanted into allogeneic animals. In all cases the transplanted tissues became well vascularized within three to five days and showed significant increases in both area and mass within eleven days. Insulin synthesis in the cryopreserved pancreas tissues was demonstrated by ability to reverse experimental diabetes in four rats. (CH)

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 7220763
• Journal Information: Transplant. Proc.; (United States), Vol. 9:1; Conference: 6. international congress of the Transplantation Society proceedings, New York, NY, USA, 22 Aug 1976
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIABETES MELLITUS
THERAPY
INSULIN
BIOSYNTHESIS
PANCREAS
PRESERVATION
TRANSPLANTS
BIOLOGICAL REGENERATION
VIABILITY
CRYOGENICS
FETUSES
GRAFT-HOST REACTION
LOW TEMPERATURE
RATS
TEMPERATURE DEPENDENCE
TISSUES
ANIMALS
BIOLOGICAL RECOVERY
BODY
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
MAMMALS
ORGANS
PEPTIDE HORMONES
RECOVERY
RODENTS
SYNTHESIS
VERTEBRATES
551000* - Physiological Systems