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Treated of type 1 diabetes mellitus in non-obese diabetic mice by transplantation of allogeneic bone marrow and pancreatic tissue

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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Non-obese diabetic (NOD) mice provide a model for type 1 diabetes mellitus. We previously showed that allogeneic bone marrow transplantation (ABMT) can prevent and treat insulitis and overt diabetes in NOD mice. However, ABMT alone could not be used to treat overt diabetes in NOD mice whose islets had been completely destroyed. To provide insulin-producing cells, pancreatic tissue from newborn mice was grafted under the renal capsules in combination with ABMT. The aims of concomitant ABMT are as follows. (i) It induces immunological tolerance to the donor-type major histocompatibility complex determinants and permits the host to accept subsequent pancreatic allografts from the bone marrow donor. (ii) ABMT replaces abnormal stem cells with normal stem cells. After transplantation of bone marrow plus newborn pancreas, NOD mice showed reduction of the glycosuria and a normal response in the glucose-tolerance test. Immunohistological study revealed the presence of clustered insulin-containing beta cells in the grafted pancreatic transplants. ABMT may become a viable treatment of established type 1 diabetes mellitus in humans.
Research Organization:
Liver Research Center, Moriguchi City (Japan)
OSTI ID:
7141793
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:18; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CARBOHYDRATES
DIABETES MELLITUS
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
GLUCOSE
HEMATOPOIETIC SYSTEM
HEXOSES
HISTOLOGY
HORMONES
IMMUNITY
IMMUNOASSAY
IMMUNOLOGY
IMMUNOTHERAPY
INSULIN
ISOTOPE APPLICATIONS
MAMMALS
METABOLIC DISEASES
MICE
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PEPTIDE HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RODENTS
SACCHARIDES
THERAPY
TISSUES
TRACER TECHNIQUES
TRANSPLANTS
VERTEBRATES