Urinary. beta. /sub 2/-microglobulin excretion among people exposed to cadmium in the general environment

Journal Article · Fri Apr 01 04:00:00 EST 1977 · Environ. Res.; (United States)

OSTI ID:7220733

Kjellstroem, T ^[1]; Shiroishi, K; Evrin, P E

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1. Karolinska Inst. and National Environment Protection Board, Stockholm

In a cadmium-exposed area, 138 farming women between 51 and 60 years of age and 40 reference women in the same age group were studied. Cadmium exposure was estimated from data on cadmium concentration in the individual farm's rice production and on individual residence times. Possible cadmium exposure from the consumption of river water was also taken into account. The average urinary cadmium concentration was about twice as high in the exposed group as in the reference group. Cadmium levels in the blood among the exposed persons were also considerably elevated. Urinary ..beta../sub 2/-microglobulin excretion was measured quantitatively as an indicator of renal tubular changes. Increased excretion was strongly related to residence time in the exposed area as well as to the use of contaminated river water in the household. Among the 35 women who had lived only at one place within the exposed area and who had not consumed river water, there was a tendency toward increased ..beta../sub 2/-microglobulin excretion with an increased cadmium level in rice and increased residence time. There was also a correlation between cadmium levels in the blood and ..beta../sub 2/-microglobulin excretion.

• OSTI ID: 7220733
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 13:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BIOMASS
BLOOD
BODY
BODY FLUIDS
CADMIUM
CEREALS
CLEARANCE
ELEMENTS
ENERGY SOURCES
EPIDEMIOLOGY
EUROPE
EXCRETION
FRESH WATER
GRAMINEAE
GRASS
HYDROGEN COMPOUNDS
JAPAN
KIDNEYS
MAMMALS
MAN
METALS
ORGANS
OXYGEN COMPOUNDS
PLANTS
POLLUTION
PRIMATES
RENAL CLEARANCE
RENEWABLE ENERGY SOURCES
RICE
SCANDINAVIA
SWEDEN
TUBULES
URINE
VERTEBRATES
WASTES
WATER
WATER POLLUTION