Urinary beta 2-microglobulin concentration and mortality in a cadmium-polluted area
- Kanazawa Medical Univ., Ishikawa (Japan)
A 9-y follow-up study of 3,178 persons who lived in a cadmium-polluted area was conducted to assess the influence of environmental cadmium exposure on long-term outcome. The standardized mortality ratios of the urinary beta 2-microglobulin-positive subjects (> 1,000 micrograms/g creatinine) of both sexes were higher than those of the general Japanese population, whereas the cumulative survival curves were lower than those of the urinary beta 2-microglobulin-negative group. A significant association was also found between urinary beta 2-microglobulin and mortality, using a Cox's proportional hazards model. Moreover, mortality rates increased in proportion to increases in the amount of urinary beta 2-microglobulin excreted. These results suggest that the prognosis for cadmium-exposed subjects with proximal tubular dysfunction is unfavorable. The mortality rate tended to become higher as the severity of renal dysfunction progressed.
- OSTI ID:
- 5604695
- Journal Information:
- Archives of Environmental Health; (United States), Journal Name: Archives of Environmental Health; (United States) Vol. 48:6; ISSN AEHLAU; ISSN 0003-9896
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
AGED ADULTS
ASIA
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CADMIUM
DEVELOPED COUNTRIES
ELDERLY PEOPLE
ELEMENTS
ENVIRONMENTAL EXPOSURE
GLOBULINS
GLOBULINS-BETA
HUMAN POPULATIONS
JAPAN
MATERIALS
METALS
MINORITY GROUPS
MORTALITY
ORGANIC COMPOUNDS
POPULATIONS
PROTEINS
SURVIVAL CURVES
TOXICITY
URINE
WASTES