Prognostic factors of renal dysfunction induced by environmental cadmium pollution

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Environmental Research; (United States)

DOI:https://doi.org/10.1006/enrs.1994.1010· OSTI ID:7104317

Nishijo, Muneko; Nakagawa, Hideaki; Morikawa, Yuko; Tabata, Masaji; Senma, Masami; Kitagawa, Yumiko; Kawano, Shunichi; Ishizaki, Masao ^[1]; Sugita, Naomichi; Nishi, Masami ^[2]

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1. Kanazawa Medical Univ., Uchinada, Ishikawa (Japan)
2. Health Authority of Ishikawa, Kanazawa, Ishikawa (Japan); and others

To assess the influence of environmental cadmium (Cd) exposure on long-term outcome, a follow-up study was conducted from 1981-1982 to March 1991 on 3178 inhabitants living in the Cd-polluted Kakehashi River basin. The standardized mortality ratios of the urinary [beta][sub 2]-microglobulin ([beta]2-MG)-, protein-, and amino acid-positive subjects of both sexes and the urinary glucose-positive female subjects were higher than those of the subjects with urinary-negative findings or the general Japanese population during the observation period. After adjusting for age using Cox's proportional hazards model, significant associations were found between mortality and urinary indices. In multiple comparisons using all of the indices, urinary protein and [beta]2-MG in the women and urinary protein in the men were the factors most contributing to the mortality rates. In the urinary protein-negative female group as well, as significant association was found between urinary [beta]2-MG and mortality. These results suggest that the prognosis of subjects with Cd-induced renal dysfunction is unfavorable, with the mortality rate increasing even in the early stage of proximal tubular dysfunction. Urinary protein and urinary [beta]2-MG are important prognostic factors, with the latter, in particular, considered to be useful as an early index predictive of premature mortality. 30 refs., 6 tabs.

• OSTI ID: 7104317
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 64:2; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CADMIUM
DISEASES
ELEMENTS
MATERIALS
METALS
MORTALITY
NEPHROSCLEROSIS
ORGANIC COMPOUNDS
PROTEINS
TOXICITY
URINE
UROGENITAL SYSTEM DISEASES
VASCULAR DISEASES
WASTES