In vivo--in vitro studies of the evolution of epithelial neoplasia

Conference · Sat Jan 01 04:00:00 EST 1977

OSTI ID:7218591

Nettesheim, P.; Marchok, A.; Terzaghi, M.

The hypothesis of neoplastic development is that following initiating events, progressively changing cell populations emerge which possess an increasing propensity to acquire the biological properties of cancer cells. Morphologically and biochemically abnormal cells appear during the latency period which constitutes what are believed to be preneoplastic lesions. Evidence for this hypothesis is discussed. An experimental model for the study of incipient neoplasia is described with regard to an in vivo system for exposure to carcinogens and an in vitro system for analysis of cellular changes. In vivo-in vitro studies with the explant-outgrowth system and with dispersed epithelial cells are also described. The altered growth capacity of carcinogen-exposed cells is discussed. (HLW)

• Research Organization: Oak Ridge National Lab., TN (USA)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 7218591
• Report Number(s): CONF-770130-1
• Country of Publication: United States
• Language: English

Related Subjects

550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BIOCHEMISTRY
BIOLOGICAL MODELS
BODY
CHEMISTRY
DISEASES
EPITHELIUM
IN VITRO
IN VIVO
MORPHOLOGICAL CHANGES
NEOPLASMS
TISSUES
TUMOR CELLS