Phenotypic changes in epithelial-cell population undergoing neoplastic transformation in vitro
Conference
·
OSTI ID:5175188
Changes were examined in DNA content and cell surface antigen expression (two unrelated cell markers) as carcinogen altered rat tracheal cells acquire the neoplastic phenotype in vitro. The coordinate change of DNA content and antigen expression as cultures change from preneoplastic to neoplastic with no detectable intermediate phenotypes indicate that neoplastic potential is acquired in a single (or a few rapid sequential) changes in this in vitro model of progression.
- Research Organization:
- Oak Ridge National Lab., TN (USA); National Inst. of Environmental Health Sciences, Research Triangle Park, NC (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5175188
- Report Number(s):
- CONF-820439-1; ON: DE82013455
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550300 -- Cytology
550400 -- Genetics
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BIOLOGICAL INDICATORS
BIOLOGICAL MODELS
BODY
CELL CONSTITUENTS
CELL CULTURES
CELL MEMBRANES
CORRELATIONS
DNA
EPITHELIUM
IN VITRO
MAMMALS
MEMBRANES
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PHENOTYPE
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SURFACES
TISSUES
TRACHEA
VERTEBRATES
550300 -- Cytology
550400 -- Genetics
550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BIOLOGICAL INDICATORS
BIOLOGICAL MODELS
BODY
CELL CONSTITUENTS
CELL CULTURES
CELL MEMBRANES
CORRELATIONS
DNA
EPITHELIUM
IN VITRO
MAMMALS
MEMBRANES
NUCLEIC ACIDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
PHENOTYPE
RATS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
SURFACES
TISSUES
TRACHEA
VERTEBRATES