Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Correlation between the DNA content and neutrophil granulocyte size in the presence of radiation pathology. [X radiation, rats]

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:7218556
; ; ; ; ;
The cytophotometric method was used to study the DNA content of myeloid elements of bone marrow of x-irradiated rats. Results showed that most of the nuclei of mature neutrophils from irradiated rats were distributed in three classes of ploidy, diploid, tetraploid, and octaploid. As early as 2 hrs after radiation, an increased percentage of young leukocytes with a double amount of DNA was observed. By the 24th hr the number of neutrophils with tetraploid DNA content reached a maximum. The study confirmed the existence of a direct relationship between radiation dose and number of enlarged and giant neutrophil cells formed in bone marrow of irradiated animals; it was shown that the largest number of polyploid forms appeared 18 hrs after radiation and the larger the cell the higher its ploidy. (HLW)
Research Organization:
Tomsk State Medical Inst., USSR
OSTI ID:
7218556
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:1; ISSN RADBA
Country of Publication:
United States
Language:
English

Similar Records

Role of direct and mediated effects of ionizing radiation in the mechanism of formation of macropolycytes. [X rays; rats]
Journal Article · Wed Feb 28 23:00:00 EST 1979 · Radiobiology (USSR) (Engl. Transl.); (United States) · OSTI ID:5388463
Effect of heterologous DNA on incidence of radiation lesions to somatic cell chromosomes of lethally irradiated animals. [Rats]
Journal Article · Fri Dec 31 23:00:00 EST 1976 · Radiobiology (USSR) (Engl. Transl.); (United States) · OSTI ID:5205410
THE TRANSFUSION OF H$sup 3$-THYMIDINE LABELED HOMOLOGOUS BONE MARROW INTO TOTAL BODY IRRADIATED RATS
Journal Article · Thu Dec 31 23:00:00 EST 1959 · Nuclear-Med. · OSTI ID:4148166

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CELL CONSTITUENTS
CELL NUCLEI
CYTOLOGICAL TECHNIQUES
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
NEUTROPHILS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOTOMETRY
PLOIDY
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SIZE
TISSUES
VERTEBRATES
VOLUME
X RADIATION